The Hong Kong Tuberculosis, Chest and Heart Diseases Association Scientific Committee on Lung Health Final report
نویسنده
چکیده
7. Timetable of Work: Document the study progress according to the proposed timetable. This study involved eligible culture isolates of M. tuberculosis consecutively received by Queen Mary Hospital Microbiology Laboratory serving patients in Queen Mary Hospital and Graham Hospital with M. tuberculosis isolated since 1 Jun 2013. During the first month of study (March 2015), ordering of necessary reagents were completed and the recruited Research Assistant was trained to perform PZA susceptibility testing. For the first 30 culture isolates, complete concordance of PZA susceptibility testing result were exhibited by both standard and reduced inoculums but one of the 30 culture isolates failed to grow in the MGIT with reduced inoculums. The study finished with another 120 culture isolates that a total of 150 culture isolates were used for the comparative study. Another 21 achieved PZA resistant strains were also collected for the comparative study. Pyrazinamidase (PZase) activity and DNA sequencing of pncA gene were compared between PZA susceptible and resistant isolates.
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